Assembly of a Fab1 Phosphoinositide Kinase Signaling Complex Requires the Fig4 Phosphoinositide Phosphatase
نویسندگان
چکیده
منابع مشابه
Phosphoinositide Signaling: Vac to the Future in Fab1 Kinase Regulation
The Fab1 protein is a phosphatidylinositol 3-phosphate 5-kinase involved in yeast stress response and membrane trafficking. New evidence indicates that the Vac14 protein, like Vac7p, regulates phosphatidylinositol 3,5-bisphosphate levels and possibly Fab1p activity.
متن کاملRole of the phosphoinositide phosphatase FIG4 gene in familial epilepsy with polymicrogyria.
OBJECTIVE The aim of this study was to identify the causal gene in a consanguineous Moroccan family with temporo-occipital polymicrogyria, psychiatric manifestations, and epilepsy, previously mapped to the 6q16-q22 region. METHODS We used exome sequencing and analyzed candidate variants in the 6q16-q22 locus, as well as a rescue assay in Fig4-null mouse fibroblasts and immunohistochemistry of...
متن کاملDeleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.
Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P(2) are responsible for the recessive peripheral-nerve disorder CMT4J. We now describe nonsynonymous variants of FIG4 in 2% (9/473) of patients with amyotrophic lateral sclerosis (ALS) and primary lateral sclerosis (PLS). Heterozygosity for a deleterious allele of FIG4 appears to be a risk factor for ALS and PLS, extending the list ...
متن کاملElectroacupuncture attenuates chronic fibromyalgia pain through the phosphorylated phosphoinositide 3-kinase signaling pathway in the mouse brain
Objective(s): Fibromyalgia (FM) is a central nervous system disorder characterized by widespread mechanical hyperalgesia due to unknown mechanisms. Several inflammatory mediators, such as interleukin-1 (IL-1), IL-6, IL-8, and tumor necrosis factor, are increased in the serum of FM patients. Although medications including pregabalin, duloxetine, and milnacipran are used...
متن کاملNotch-induced T cell development requires phosphoinositide-dependent kinase 1
Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and proliferation, and herein, we explore the molecular basis for these essential functions of PDK1 in T lymphocyte development. A key finding is that P...
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ژورنال
عنوان ژورنال: Molecular Biology of the Cell
سال: 2008
ISSN: 1059-1524,1939-4586
DOI: 10.1091/mbc.e08-04-0405